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KMID : 1149220120200010001
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Korean Journal of Oriental Medical Prescription
2012 Volume.20 No. 1 p.1 ~ p.11
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Combination with Korean Red Ginseng and Gastrodia rhizoma Enhances Vascular Protective Effects in Hyperlipidemic Rats
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Lee Yun-Jung
Kim Hye-Yoom
Yoon Jung-Joo
Lee So-Min
Kho Joung-hyun
Lee Ho-Sub
Choi Kyung-Min
Kang Dae-Gil
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Abstract
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Objectives: This experimental study was designed to investigate the inhibitory effects of combination with Korean red ginseng and Gastrodia rhizoma on vascular dysfunction in high-fat/cholesterol diet-induced hyperlipidemia.
Methods: Sprague-Dawley rats were fed with 7.5% cocoa butter and 1.25% cholesterol for 10 weeks, with Panax ginseng (PG), and mixtures of Panax ginseng and Gastrodia rhizoma (PGM), respectively.
Results: Chronic treatment with PG and PGM significantly decreased body weight. The aortic expression of cell adhesion molecules such as intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin were markedly increased in hyperlipidemia rats. Interestingly, PGM significantly decreased cell adhesion molecules expression. However, there was no significant decrease in PG group. In addition, PG and PGM group inhibited high-fat/cholesterol diet-induced cytokine such as monocyte chemoattractant protein (MCP-1) mRNA expression. Furthermore, PG and PGM group significantly decreased c-reactive protein protein (CRP) level. Especially, PGM significantly accentuated the decrease of MCP-1 mRNA expression and CRP level.
Conclusions: the present study provides an evidence that combination with Panax ginseng and Gastrodia rhizoma enhances anti-vascular protective effects through suppression of vascular inflammation in hyperlipidemic rats.
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KEYWORD
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Panax ginseng C.A. Meyer, Gastrodia rhizoma, vascular inflammation, high fat/holesterol diet, CRP
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